Cutaneous Sensitization Studies
نویسندگان
چکیده
منابع مشابه
Studies in Rh Sensitization
By ALEXANDER S. WIENER, M.D., F.A.C.P., RAFFAELE NAPPI, M.D. AND EVE B. GORDON I N THE PRECEDING PAPER’ our methods for performing Rh antibody titrations were described in detail, with special reference to the precautions taken to insure objective and reproducible results. Using these technics, it was shown that pregnancies with Rh-negative fetuses and the birth of Rh-negative babies have no si...
متن کاملStudies in Sensitization to Skin
1. Techniques for the preparation of skin antigen suitable for intramuscular injection in rabbits, and of skin antigens (autolysate) for serological experiments are described. 2. A method was evolved which produced a soluble skin antigen (autolysate) suitable for performing precipitin tests. 3. Injection of the rabbit skin antigen and of staphylococcus toxin in rabbits resulted in the formation...
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C-Fiber mechanoheat (C-MH) nociceptors from the saphenous nerve were studied, in control rats and in rats that underwent surgical sympathectomy. Intradermal injection, alone, of either norepinephrine (NE) or the calcium ionophore, A23187, did not affect mechanical threshold. The combination of A23187 and NE, however, significantly decreased mechanical threshold. In the presence of the alpha 2-a...
متن کاملEpidermal barrier dysfunction and cutaneous sensitization in atopic diseases.
Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies, cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators' attention on epidermal barrier dysfunction as a causative mechanism. The skin's barrier function has three elements: the stratum corn...
متن کاملHealthy Volunteers Can Be Phenotyped Using Cutaneous Sensitization Pain Models
BACKGROUND Human experimental pain models leading to development of secondary hyperalgesia are used to estimate efficacy of analgesics and antihyperalgesics. The ability to develop an area of secondary hyperalgesia varies substantially between subjects, but little is known about the agreement following repeated measurements. The aim of this study was to determine if the areas of secondary hyper...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1939
ISSN: 0022-202X
DOI: 10.1038/jid.1939.9